Your audio system should probably be multi-source so you can have different music in each room and so you don’t need to strain to hear music from a location farther away in the house. Of course, you might do OK with a single-source system if you need just one amplifier (like if you live alone and spend most of your time in one area of the house). The three main considerations that go into single-source vs. multi are the number of people living in the house, their music preferences and which rooms you want music in/how close the rooms are to one another.
The best way to think of structured wiring is to imagine all the communications cables for your audio and video systems as a single, integrated system of wiring. The big advantage to structured wiring is that it has a central location to which all the cables from individual systems are directed, with all the wiring for phone, video, network, and TV bundled together. Because all cables come in to the central wiring panel, any kind of changes are made easy, and troubleshooting is also much simpler. Best of all, it always results in more consistent signal quality for each individual system, because they all have the same source and receive the same signal level. This kind of wiring scheme also allows you to use high-quality cable throughout the entire network, giving you the absolute best framework for high-quality entertainment.